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一种检测帕金森病等疾病病人肠道Akk丰度变化及其基因型分布的方法

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摘要

本发明公开了一种检测帕金森病(Parkinson’s disease,PD)等疾病病人肠道Akk丰度变化及其基因型分布的方法，包括采集粪便样品；提取粪便DNA；实时荧光定量PCR(RT‑qPCR)检测粪便DNA中AkkⅠ和AkkⅡ，AkkⅢ的相对丰度。优点有：利用RT‑qPCR建立了快速分析肠道内Akk三个亚型分布的方法，能够初步探讨Akk亚型丰度的变化与PD等疾病的相关性，为后续探讨Akk不同亚型的作用机制做铺垫，并可能为日后PD等疾病的预防和治疗提供新的思路。

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公开/公告号CN111471778A

专利类型发明专利
公开/公告日2020-07-31

原文格式PDF
申请/专利权人广州康泽医疗科技有限公司;彭永正;
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申请/专利号CN202010075763.8
发明设计人彭永正;黄东泉;易江丰;
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申请日2020-01-22
分类号C12Q1/689(20180101);C12Q1/686(20180101);C12Q1/04(20060101);C12N15/11(20060101);C12R1/01(20060101);
代理机构36124 新余市渝星知识产权代理事务所(普通合伙);
代理人廖平
地址 510000 广东省广州市天河区中山大道358号大院自编5号楼229房
入库时间 2023-12-17 10:46:11

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2020-07-31

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1. 一种检测帕金森病等疾病病人肠道Akk丰度变化及其基因型分布的方法 [P] . 中国专利： CN111471778A . 2020-07-31
2. 连翘叶提取物及其用于提高肠道AKK菌丰度的用途 [P] . 中国专利： CN113599417A . 2021-11-05
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机译：减少动物死亡，肠道病原体中强毒表达以及细菌细胞中粘附素/凝集素pa-i表达，抑制肠道病原体中粘附素/凝集素pa-i表达，肠道诱导的粘附素活化的方法/凝集素pa-i，c4-hsl诱导的肠道病原体形态变化和哺乳动物肠道细菌细胞粘附，改善肠道发病机制，预防疾病或异常状况，皮肤和呼吸道感染，性传播疾病，消化道疾病，动物泌乳能力的丧失以及哺乳期动物中微生物介导的上皮疾病的发展，至少一部分尿路的冲洗以及用于监测聚乙二醇（peg）的给药动物，组合物药物，用于预防或治疗肠源性败血症并监测多乙
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机译：分离的多核苷酸，鉴定或扩增和多核苷酸的全部或部分基因型，分离多肽，获得免疫特异性抗体，鉴定一种或多种待测化合物之间的试剂和化合物，分析其生物学特性的方法患者，以预防或治疗与基因组中多核苷酸的存在有关的疾病和病症或疾病，以增加或降低多肽患者的活性，以统计学方式确定至少一种snp是疾病或抗病性以及用于诊断或确定疾病预后或抗病性的重组载体，宿主细胞，多肽，免疫特异性抗体，治疗剂和化合物
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