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分离生物小分子的整体硅胶柱及其制备方法,和分离生物小分子的方法

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摘要

本发明公开了分离生物小分子的整体硅胶柱，其具有硅胶基体和在该硅胶基体上形成的孔隙，该硅胶基体和孔隙在其表面已经用聚合物改性，使得表面改性的孔隙具有与要分离的生物小分子的分子大小相当的孔尺寸，该聚合物通过聚合单体组合物而得到，该单体混合物包括下式(1)所示的含磷酸胆碱类似基团的单体：

著录项

公开/公告号CN101804336B

专利类型发明专利
公开/公告日2012-08-08

原文格式PDF
申请/专利权人索尼公司;
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申请/专利号CN201010114749.0
发明设计人胜原智子;松本真宽;石原一彦;
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申请日2010-02-20
分类号
代理机构北京市柳沈律师事务所;
代理人吴培善
地址日本东京都
入库时间 2022-08-23 09:11:03

法律信息

法律状态公告日

法律状态信息

法律状态
2016-04-06

未缴年费专利权终止 IPC(主分类):B01J 20/283 授权公告日:20120808 终止日期:20150220 申请日:20100220

专利权的终止
2012-08-08

授权

授权
2010-10-06

实质审查的生效 IPC(主分类):B01J 20/283 申请日:20100220

实质审查的生效
2010-08-18

公开

公开

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1. 分离生物小分子的整体硅胶柱及其制备方法,和分离生物小分子的方法 [P] . 中国专利： CN101804336B . 2012.08.08
2. 一种适用于小分子和生物大分子分离的逆流色谱分离柱 [P] . 中国专利： CN201143392Y . 2008.11.05
3. isolated polynucleotide, expression cassette, host cell, isolated polypeptide, non-human transgenic animal that has been altered to express an alkali resistant mutant polypeptide, an antibody that specifically binds to an alkali resistant mutant polypeptide, a mutation detection kit alk inhibitor resistance in a biological sample, and methods for evaluating a biological sample for an alk inhibitor resistance mutation to diagnose cancer that is resistant to or likely to develop resistance to at least one alkaline inhibitor. small alk molecule kinase, to evaluate a biological sample for an alk inhibitor resistance mutation, to diagnose cancer that is resistant to or likely to develop resistance to pf-02341066 in a patient, to specifically reduce expression of an alk-resistant mutant to treat cancer associated with activating aberrant loop capacity that is resistant to at least one small molecule alk kinase inhibitor treating an aberrant cancer that is resistant to pf-02341066, identifyin [P] . BR112012026239A2 . 2018-06-26

机译：分离的多核苷酸，表达盒，宿主细胞，分离的多肽，已被改变以表达耐碱突变体多肽的非人类转基因动物，与耐碱突变体多肽特异性结合的抗体，突变检测试剂盒生物样品，以及用于评估生物样品中是否存在对烷基抑制剂的抗性突变以诊断对至少一种碱性抑制剂有抗药性或可能发展出抗药性的癌症的方法。小分子激酶，用于评估生物学样品中是否具有抑制碱性磷酸酶抑制剂的突变，以诊断对患者具有抗药性或可能对pf-02341066产生抗药性的癌症，从而特异性降低抗癌突变体的表达以治疗癌症与激活抗至少一种小分子烷基激酶抑制剂的异常环路能力有关，该抑制剂治疗对pf-02341066有抵抗力的异常癌症
4. Polinucleotu00eddeo insulated tape of expression, host cell, isolated transgenic non-human animal polypeptide, which has been modified to express a polypeptide mutant with resistance to ALK, antibody that binds specifically to a polypeptide mutant with resistance to ALK, kit p For detection of a mutation with resistance to ALK inhibitor in a biological sample, and,Methods for evaluating a biological sample as a mutation with resistance to ALK inhibitor, for diagnosing a cancer that is resistant to or is likely to develop resistance to at least one inhibitor of kinase small molecule ALK, to evaluate a biological sample that Anto a mutation with resistance to ALK inhibitor.For diagnosing a cancer that is resistant to or is likely to develop resistance to at least one inhibitor of kinase small molecule ALK, to assess the biological sample as a mutation with resistance to ALK inhibitor, a cancer that is resistant to dianosticar Or is likely to develop resistance to PF - 02341066 in a pati [P] . BR112012026239A2 . 2016-11-29

机译：修饰的多聚核苷酸绝缘带，宿主细胞，分离的转基因非人类动物多肽，经过修饰以表达对ALK具有抗性的多肽突变体，与对ALK具有抗性的多肽突变体特异性结合的抗体，试剂盒p用于检测生物样品中对ALK抑制剂具有抗性的突变，以及用于评估生物样品为对ALK抑制剂具有抗性的突变的方法，用于诊断对至少一种对ALK抑制剂具有抗性或可能发展出抗性的癌症激酶小分子ALK，以评估Anto对ALK抑制剂具有抗性的突变的生物样品。用于诊断对至少一种激酶小分子ALK抑制剂具有抗药性或可能产生抗性的癌症，以评估该生物样品作为对ALK抑制剂有抗性的突变，即对狄诺司他抗性或可能对PF产生抗药性的癌症-02341066
5. BIOMICROMOLECULE-SEPARATING, MONOLITHIC SILICA COLUMN AND ITS PRODUCTION PROCESS, AND SEPARATION METHOD OF BIOMICROMOLECULES [P] . 美国专利： US2010210458A1 . 2010-08-19

机译：生物微分子分离，硅胶柱及其生产过程，生物微分子的分离方法