Near Infrared Spectroscopy for Improving Breast Core Needle Biopsy

摘要

The objective of the proposed research is to develop a device to reduce the frequency of breast re-excision surgery in patients with breast malignancies. The purpose of Task 2 was to build and test a fiber optic probe with two imaging channels. The fiber geometry of this probe showed that collected data was repeatable and accurate at extracting known optical properties. The purpose of Task 3 was to build a multi-channel imaging probe which was constructed with 19,200 illumination fibers and 4,200um collection fibers. The objective of Task 4 was to test the multi-channel imaging probe on tissue phantom data and partial mastectomy specimens. Tissue phantom studies revealed that data can be accurately extracted with the current imaging system and multi-channel fiber optic probe. To date partial mastectomy margins have been imaged on 43 patients and show statistically significant differences between negative and close/positive surgical margins.