Relation of Fever to Energy Expenditure.

摘要

During fever, the body continues to utilize its normal molecular machinery for generating energy, with fatty acids apparently serving as the major source of fuel. In addition, the requirements for the extra metabolizable energy associated with the presence of fever are largely met by the accelerated hepatic synthesis of glucose. The need to synthesize larger quantities of glucose is filled principally by the use of amino acid substrates which are supplied by the catabolism of proteins in muscle and other somatic tissues and the synthesis of gluconeogenic amino acids within muscle. Despite the concomitant presence of varying degrees of starvation in a febrile individual, ketone synthesis is depressed. Little is known about fever-energy production relationships during states of protracted fever or in the presence of a severe depletion in body protein stores. (Author)