Modified of an Accepted Animal Model of Osteomyelitis to Simulate and Evaluate Treatment of War Extremity Wounds. Addendum.

摘要

The primary goal of this project is to evaluate the efficacy of selected antibiotic regimens in an established osteomyelitis animal model of infection from MRSA, Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae. A related arm of the project at the University of Maryland-Baltimore will identify microbial gene products of the four species mentioned above with upregulated production in biofilms using two-dimensional (2D) gel electrophoresis. In addition, the PI has worked with military collaborators to publish a series of peer-reviewed manuscripts outlining guidelines for prevention and management of infections.