Phomoxins B and C: Polyketides from an endophytic fungus of the genus Eupenicillium

摘要

Chemical investigations of the culture broth from an endophytic fungus Eupenicillium sp. have afforded two natural products pho-moxins B (1) and C (2) as well as the previously reported fungal metabolite eupcnoxide (3). Compounds 1 and 2 both containa cyclic carbonate moiety that is rare among natural products. This paper reports the full spectroscopic characterisation of phomoxins B (1) and C (2) by NMR, UV, IR and MS data. All compounds were inactive against a panel of nosocomial microbes.