Kynurenic acid: A new effector of valproate action?

摘要

We investigated the changes in hippocampal kynurenic acid (KYNA) concentrations and the amino acids involved in neuronal activity regulation following valproate (VPA) administration (400 mg/kg ip) in pentylenetetrazole- kindled rats (in vivo).We found a remarkably long-lasting increase in KYNAlevels following VPAadministration, and this effect correlated with a rise in GABAlevels. No changes in the concentration of other analyzed amino acids were present. It is likely that the antiepileptic and neuroprotective properties of VPA may also be a consequence of an increase in the hippocampal KYNA concentration.