New synthesis of 2-thioxoethylphosphonates, 2-mercaptovinylphosphonates, 2-phosphoryl-3-thioxopropanoates, 2-thiomethylvinylphosphonates, 2-Thioethoxycarbonylmethylvinylphosphonates

摘要

The cyanomethylphosphonates 1 and the ethyl phosphoacetates 2 were reacted with some fluorophenylisothiocyanates to give the 2-thioxoethylphosphonates 3 in tautomeric equilibrium with the corresponding 2-mercaptovinylphosphonates 3 ' and the 2-phosphoryl-3-thioxopropanoates 4, respectively. Reaction of the cyanomethylphosphonates 1 with fluorophenylisothiocyanates in presence of methyliodide furnished the 2- thiometylvinylphosphonates 5. The 2-mercaptovinylphosphonates 3 ' reacted with ethyl chloroacetate in refluxing ethanol in the presence of triethylamine to give S-substitued derivatives 6.