Current Strategies for ADMET Integration to Enhance Efficiency and Quality in Drug Discovery

摘要

In the past decade,the increased attention to biopharmaceutical "drug-like"properties in drug discovery has enhanced success and efficiency.Higher quality clinical candidates are being advanced to development.Several strategies for integration of ADMET into discovery have proven to be successful.These strategies include the following:Diverse ADMET tools (rales,in silico,in vitro,in vivo)have been developed and have found their most appropriate stages of discovery.Chemical structures,and the role of medicinal chemists in selecting and modifying structures to optimize properties,are of crucial importance.Potency and properties are evaluated and optimized in parallel.ADMET experts provide consultation on selecting and optimizing lead candidates with optimal properties,as part of collaborative project teams.ADMET property knowledge has been successfully applied beyond in vivo drug delivery to optimizing in vitro biological assays.