EFFICIENT OXIDATION OF THE HANTZSCH 1,4-DIHYDROPYRIDINES USING POTASSIUM IODIDE AND OXONE

摘要

A mild and efficient aromatisation of the Hantzsch 1,4-dihydropyridine with potassium peroxomonosulphate-potassium iodide is reported. The oxone-KI system converts 1,4-dihydropyridines to their corresponding pyridine derivatives at room temperature in a 1:1 CH3CN/H2O mixture. The ability of various halide salts in the oxidation of 1,4-dihydropyridines was also investigated.