ONE-POT SeO2 OXIDATION OF STEROIDAL ALKENES

摘要

Oxidation of 3β-hydroxycholest-5-ene and 3β-acetoxycholest-5-ene with selenium dioxide (SeO2) provides cholset-4-en-3-one. Cholest-5-ene on similar oxidation gave cholest-5-en-4-one, cholest-5-en-7-one and 7β-hydroxycholest-5-ene. The structures are supported by their physical and spectral properties (IR, ~1H NMR, ~(13)C NMR). The method is economical, environmentally friendly, convenient, one-pot transformation of alkene to the corresponding ketone/s.