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The role of the PD-L1:PD-1 pathway in squamous cell carcinoma of the head and neck

机译:PD-L1:PD-1通路在头颈部鳞状细胞癌中的作用

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Antigen specific stimulation of immune cells, triggers expression of a diverse array of co-signaling molecules that help define the fate of the resultant immune response. Antibodies and fusion proteins, capable of blocking and/or activating these co-signaling pathways, are emerging as potent therapeutic options for the treatment of cancer and autoimmune disease. Blockade of one such pair of co signaling interactions, termed PD-L1:PD-1, has shown tremendous promise in phase I treatment trials for advanced solid tumors like non-small cell lung cancer and melanoma, with long term disease remission in select patients. Based on intriguing preclinical data from our group and others, several trials are actively evaluating the utility of PD-L1:PD-1 blockade for the treatment of recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN). In this review we will explore what is known about the interactions between PD-1 and PD-L1, with a focus on SCCHN, and specifically discuss how this pathway can be manipulated with therapeutic intent.
机译:免疫细胞的抗原特异性刺激触发了多种共信号分子的表达,这些信号有助于确定最终免疫反应的命运。能够阻断和/或激活这些共同信号通路的抗体和融合蛋白作为治疗癌症和自身免疫性疾病的有效治疗选择正在兴起。一对这样的协同信号相互作用被称为PD-L1:PD-1的阻断在I期治疗试验中显示出了对晚期实体瘤(如非小细胞肺癌和黑素瘤)的巨大希望,并能长期缓解某些患者的疾病。基于来自我们小组和其他组织的有趣的临床前数据,一些试验正在积极评估PD-L1:PD-1阻滞剂在治疗复发/转移性头颈部鳞状细胞癌(SCCHN)中的效用。在这篇综述中,我们将探讨关于PD-1和PD-L1之间相互作用的已知知识,重点是SCCHN,并具体讨论如何通过治疗目的来操纵该途径。

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