Human Brown Adipose Tissue Assessed by Simple, Noninvasive Near-Infrared Time-Resolved Spectroscopy

摘要

ObjectiveHuman brown adipose tissue (BAT) activity has been typically evaluated by F-18-fluorodeoxyglucose (FDG)-positron emission tomography (PET) combined with computed tomography (CT). However, FDG-PET/CT has serious limitations (e.g., radiation and cold exposure). This study evaluated BAT density using near-infrared time-resolved spectroscopy (NIRTRS), a simple and noninvasive method of measuring the indices of tissue hemoglobin concentration [total-Hb] and mitochondrial density (mu(s)).