Synthesis and Antioxidant Activity of Biocompatible Maltodextrin-Stabilized Aqueous Sols of Nanocrystalline Ceria

摘要

A novel method is proposed for preparing biocompatible aqueous CeO_2 sols, which allows purposefully adjusting particle sizes and biochemical properties of nanocrystalline ceria (NC). The usefulness of this method for preparing aqueous sols of Ce_(1-x)Gd_xO_(2_x/2) solid solutions is demonstrated. Nanocrystalline ceria has been demonstrated to have a size-dependent activity in hydroxyl radical inactivation and in protecting mouse fibroblast cells (L929) from oxidative stress induced by hydrogen peroxide administration.