Synthesis of Ammonium 5-Arylcarbamoyl-4-heteryl-6-methyl-3-cyano-l,4-dihydropyridine-2-thiolates and 4-Heteryl-5-carbamoyl-6-methyl-3-cyano-l,4-dihydropyridine-2-selenolates

摘要

The condensation of enamines derived from acetoacetanilides,heterocyclic aldehydes,and cyano-thioacetamide yielded ammonium 5-arylcarbamoyl-5-heteryl-6-methyl-3-cyano-1,4-dihydropyridine-2-thio-lates,which were subsequently used for the synthesis of substituted 2-alkylthio-l,4-dihydropyridines,2-alkyl-thiopyridines,and thieno[2,3-b]pyridines.The reaction of acetoacetamide with heteroaromatic aldehydes and cyanoselenoacetamide in the presence of N-ethylmorpholine yielded N-ethylmorpholinium 4-heteryl-5-car-bamoyl-6-methyl-3-cyano-l,4-dihydrolyridine-2-selenolates,from which substituted 2-alkylseleno-l,4-di-hydropyridines were prepared.