Inhibition of JNK increases survival of transplanted dopamine neurons in Parkinsonian rats.

摘要

Parkinson's disease (PD) affects approximately 2% of the population over 65 years of age.1 This neurodegenerative disorder is caused by a selective and progressive death of the dopaminergic (DA) neurons of the substantia nigra and subsequent striatal deficiency of dopamine, resulting in movement anomalies. Vast efforts are being made to develop cell replacement therapies using fetal transplantation and stem cell based approaches to improve treatment. Proof of concept for transplantation of human fetal mesencephalic tissue into the striatum of PD patients was obtained in T987.