HLA-matching potential of an established human embryonic stem cell bank in China.

摘要

Previous studies have performed internal matching of HLA and ABO blood type data from either cadaveric organ donors (Taylor et al., 2005) or a cord blood bank (Nakajima et al., 2007) to estimate that a theoretical collection of approximately 150-170 human embryonic stem cell (hESC) lines with various HLA genotypes or a collection of ten lines homozygous for the common HLA types will suffice to provide HLA-matches for populations in the UK (Taylor et al., 2005) and Japan (Nakajima et al., 2007). In this report, we have established a hESC bank containing 188 hESC lines mainly derived from abnormal and poor-quality in vitro fertilization (IVF)-derived embryos and have evaluated the actual HLA-matching capacity of the bank with respect to the regional population. We find that the current bank could provide a beneficial match for 24.9%-56.3% of the local population, regardless of ethnic differences.