Synthesis of Indenol,2-bquinolin-10-ones via Pd/C-Assisted Dehydrogenation of 4b,5,10a,ll-Tetrahydroindenol,2-bquinolin-10-ones

摘要

Recently,we have reported the synthesis of 4b,5,10a,ll-tetrahydroindenol,2-bquinolin-10-ones starting from the acetates of Baylis-Hillman adducts as in Scheme 1.Indeno-quinoline derivatives showed a wide range of biological activities such as 5-HT-receptor binding activity,anti-inflammatory activity,and also act as antitumor agents,inhibitor for steroid reductase,acetylcholinesterase inhibitors,and antimalarials.