Extraction of Synthetic Cannabinoids Parents and Metabolites (JWH Series) from Urine, Plasma, and Whole Blood Using Supported Liquid Extraction (ISOLUTE~? SLE+) in Cartridge and 96-Well Format Prior to LC-MS-MS

摘要

Synthetic Cannabinoids, or SPICE, are synthetic compounds that bind to the cannabinoid receptors in mammals, and hence trigger similar euphoric symptoms to tetrahydrocannabinoid (THC), the active component in marijuana. A robust and fast sample extraction method from various biological matrices has been developed to aid in accurate detection and quantitation of these compounds and their metabolites. Here we demonstrate the use of supported liquid extraction (SLE) for extraction and quantitation of the parent and metabolites from the JWH series.