Transparent nanostructured photochromic UV-blocking soft contact lenses

摘要

Aim: We aim to develop transparent UV-blocking photochromic soft contact lenses via polymerization of a bicontinuous nanoemulsion. Materials & methods: Transparent nanostructured polymers were prepared by incorporating a polymerizable surfactant and thermal initiator together with water, monomers, UV blockers and photochromic dyes. The polymers were characterized using oxygen permeometer, tensile tester, electron microscope, UV spectrophotometer, corneal cell culture and testing in rabbits. Results: The polymers have good oxygen permeability, water content, stiffness, strength and UV-blocking ability comparable to commercial UV-blocking soft contact lenses. Their response to UV light is comparable to photochromic spectacle lenses, particularly in reverse transition from colored to colorless state. They are nontoxic and nonleaching. Conclusion: Our photochromic UV-blocking contact lenses provide a novel alternative to photochromic spectacles.