Alum (KAl(SO4)2 · 12H2O):An Efficient and Inexpensive Catalyst for the One-pot Synthesis of 1,3,4-Oxadiazoles under Solvent-Free Conditions

摘要

Alum (KAl(SO4)2 · 12H2O) catalyzed the efficient synthesis of mono- and disubstituted 1,3,4-oxadiazoles by the condensation of acyl hydrazides with orthoesters under solvent-free conditions at 100°C.This methodology offers significant improvements for the synthesis of oxadiazoles with regard to the yield of products,simplicity in operation,inexpensive reagents,and green aspects by avoiding toxic catalysts and solvents.