A Double Mannich-type Reaction in the 1,4,5,6-Tetrahydropyridine-2-thiolate Series: A Convenient Approach to Functionalized 3,7-Diazabicyclo[3.3.1]nonane Derivatives

Victor V. Dotsenko; Sergey G. Krivokolysko; Victor P. Litvinov

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A Double Mannich-type Reaction in the 1,4,5,6-Tetrahydropyridine-2-thiolate Series: A Convenient Approach to Functionalized 3,7-Diazabicyclo[3.3.1]nonane Derivatives

机译：1,4,5,6-四氢吡啶-2-硫酸酯系列中的双重曼尼希型反应：一种功能化的3,7-二氮杂双环[3.3.1]壬烷衍生物的简便方法

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The reaction of N-methylmorpholinium 5-alkoxy-carbonyl-4-aryl-3-cyano-2-oxo-1,4,5,6-tetrahydropyridine-2-thiolates with primary amines and formaldehyde under mild conditions afforded 7-substituted alkyl 9-aryl-5-cyano-2-oxo-4-thioxo-3,7-diazabicyclo[3.3.1]nonane-l-carboxylates in fair to good yields (52-74%).

机译：N-甲基吗啉鎓5-烷氧基-羰基-4-芳基-3-氰基-2-氧代-1,4,5,6-四氢吡啶-2-硫醇盐与伯胺和甲醛的反应在温和条件下得到7-取代的烷基9-芳基-5-氰基-2-氧代-4-硫代氧代3,7-二氮杂双环[3.3.1]壬烷-1-羧酸酯的产率中等至良好（52-74％）。

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《Monatshefte fur Chemie》 |2007年第5期|共6页
作者
Victor V. Dotsenko; Sergey G. Krivokolysko; Victor P. Litvinov;
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正文语种 eng
中图分类化学;
关键词
Heterocycles; Cyclizations; Mannich reaction; 3; 7-Diazabicyclo3.3.lnonanes; Pyridine-2-thiolates.;

机译：杂环;环化;曼尼希反应;3;7-二氮杂双环[3.3.1]壬烷;吡啶-2-硫醇盐。;

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1. A Double Mannich-type Reaction in the 1,4,5,6-Tetrahydropyridine-2-thiolate Series: A Convenient Approach to Functionalized 3,7-Diazabicyclo[3.3.1]nonane Derivatives [J] . Victor V. Dotsenko, Sergey G. Krivokolysko, Victor P. Litvinov Monatshefte fur Chemie . 2007,第5期

机译：1,4,5,6-四氢吡啶-2-硫酸酯系列中的双重曼尼希型反应：一种功能化的3,7-二氮杂双环[3.3.1]壬烷衍生物的简便方法
2. The Mannich reaction in the synthesis of N,S-containing heterocycles 8. Aminomethylation of 3,5-dicyano-6-oxo-1,4,5,6-tetrahydropyridine-2-thiolates as a method for the synthesis of new functionally substituted 3,7-diazabicyclo[3.3.1]nonane derivatives [J] . V.V.Dotsenko, S.G.Krivokolysko, V.P.Litvinov Russian Chemical Bulletin . 2007,第12期

机译：合成含N，S的杂环的曼尼希反应8. 3,5-二氰基-6-氧代-1,4,5,6-四氢吡啶-2-硫醇盐的氨甲基化，作为合成新功能取代的方法3,7-二氮杂双环[3.3.1]壬烷衍生物
3. Aminomethylation of 1,2,3,4-Tetrahydropyridine-6-thiolates: A Novel Approach to Synthesis of 3,7-Diazabicyclo[3.3.1]nonane Derivatives [J] . V. V. Dotsenko, S. G. Krivokolysko, V. P. Litvinov Chemistry of heterocyclic compounds . 2005,第11期

机译：1,2,3,4-四氢吡啶-6-硫醇盐的氨甲基化：一种合成3,7-二氮杂双环[3.3.1]壬烷衍生物的新方法
4. A Convenient Synthetic Approach to Five-membered Heterocyclic Compounds by Electrophilic 5-Endo-trig Cyclization Reactions of Bifunctionalized Allenes [C] . Valerij Ch. Christov, Jordanka G. Ivanova, Boris Prodanov European Symposium on Organic Chemistry . 2009

机译：通过双官能化甲烯的亲电5- endo-TrIG环化反应的五元杂环化合物的方便合成方法
5. Pharmacokinetic, pharmacodynamic, and toxicological studies on new antiarrhythmic agents from selected 3,7-diheterabicyclo(3.3.1)nonane derivatives. [D] . Chen, Chun-Lin. 1994

机译：从选定的3,7-二杂双环（3.3.1）壬烷衍生物中开发新的抗心律不齐药物的药代动力学，药效学和毒理学研究。
6. The 37-diazabicyclo3.3.1nonane scaffold for subtype selective nicotinic acetylcholine receptor ligands. Part 2. Carboxamide derivatives with different spacer motifs [O] . Christoph Eibl, Lenka Munoz, Isabelle Tomassoli, -1

机译：37-二氮杂双环3.3.1壬烷骨架用于亚型选择性烟碱乙酰胆碱受体配体。第2部分。具有不同间隔基序的羧酰胺衍生物
7. Crystal structures and supramolecular features of 9,9-dimethyl-3,7-diazabicyclo[3.3.1]nonane-2,4,6,8-tetraone, 3,7-diazaspiro[bicyclo[3.3.1]nonane-9,1′-cyclopentane]-2,4,6,8-tetraone and 9-methyl-9-phenyl-3,7-diazabicyclo[3.3.1]nonane-2,4,6,8-tetraone dimethylformamide monosolvate [O] . Sergey Z. Vatsadze, Marina A. Manaenkova, Evgeny V. Vasilev, 2017

机译：9,9-二甲基-3,7-二氮杂双环[3.3.1]壬烷-2,4,6,8-四酮，3,7-二氮杂螺[双环[3.3.1]壬烷-9的晶体结构和超分子特征， 1'-环戊烷] -2,4,6,8-四酮和9-甲基-9-苯基-3,7-二氮杂双环[3.3.1]壬烷-2,4,6,8-四酮二甲基甲酰胺单溶剂化物
8. Selective Reductions. XXI. 9-Borabicyclo(3.3.1) Nonane in Tetrahydrofuran as a New Selective Reducing Agent in Organic Synthesis. Reaction with Selected Organic Compounds Containing Representative Functional Groups. [R] . Brown, H. C., Krishnamurthy, S., Yoon, N. M. 1976

机译：选择性减少。 XXI。 9-Borabicyclo（3.3.1）四氢呋喃中的壬烷作为有机合成中的新型选择性还原剂。与含有代表性官能团的选定有机化合物反应。

A Double Mannich-type Reaction in the 1,4,5,6-Tetrahydropyridine-2-thiolate Series: A Convenient Approach to Functionalized 3,7-Diazabicyclo[3.3.1]nonane Derivatives

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