Synthesis of 2-aminoxazole-5-carbamides and 2-aminothiazole-5-carbamides as potent inhibitors of CML

摘要

2-Aminoxazole-5-carbamide was discovered as novel potent inhibitor against human chronic myeloid leukemia K562 cells; several new corresponding 2-aminothiazole-5-carbamides were also prepared and evaluated the biological activity. The results demonstrated that all of the new compounds exhibited antiproliferative potency on human K562 leukemia cells.