Lupus nephritis: Nucleosomes trapped by aberrantly expressed laminin-β1

HolmesD.; JonesB.

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Lupus nephritis: Nucleosomes trapped by aberrantly expressed laminin-β1

机译：狼疮性肾炎：核糖体被异常表达的层粘连蛋白-β1捕获

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Nucleosomes-key autoantigens involved in the pathogenesis of lupus nephritis (LN)-bind to aberrantly expressed laminin-beta 1 and localize to electron-dense deposits (EDDs) within the glomerular basement membrane (GBM) in patients with LN, according to the authors of a new study. In addition, the researchers report that local production of transforming growth factor (TGF)-beta 1 might drive the abnormal expression of laminin- beta 1 chains

机译：这组作者说，参与狼疮性肾炎（LN）发病机理的核小体关键自身抗原与LN患者的肾小球基底膜（GBM）内异常表达的层粘连蛋白β1结合并定位于电子致密沉积物（EDD）。一项新研究。此外，研究人员报告说，转化生长因子（TGF）-β1的局部产生可能驱动层粘连蛋白-β1链的异常表达

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《Nature reviews. Nephrology》 |2014年第1期|共1页
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HolmesD.; JonesB.;
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中图分类泌尿科学（泌尿生殖系疾病）;
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1. Lupus nephritis: Nucleosomes trapped by aberrantly expressed laminin-β1 [J] . HolmesD., JonesB. Nature reviews. Nephrology . 2014,第1期

机译：狼疮性肾炎：核糖体被异常表达的层粘连蛋白-β1捕获
2. Pathogenic Mechanisms in Lupus Nephritis Nucleosomes Bind Aberrant Laminin beta 1 With High Affinity and Colocalize in the Electron-Dense Deposits [J] . Olin Anders I., Moergelin Matthias, Truedsson Lennart, Arthritis & rheumatology. . 2014,第2期

机译：狼疮性肾炎核小体的致病机制以高亲和力和电子致密沉积共定位结合异常层粘连蛋白β1。
3. Nucleosomes contribute to increase mesangial cell chemokine expression during the development of lupus nephritis [J] . KanapathippillaiP., HedbergA., FentonC.G., Cytokine . 2013,第2期

机译：核心有助于在狼疮肾炎的发育过程中增加髓鞘细胞趋化因子表达
4. IgA Nephropathy and Henoch-Schoenlein Purpura Nephritis: Aberrant Glycosylation of IgAI, Formation of lgA1-Containing Immune Complexes, and Activation of Mesangial Cells [C] . Jan Novak, Zina Moldoveanu, Matthew B. Renfrow, International Symposium on IgA Nephropathy . 2007

机译：Iga肾病和henoch-schoenlein purpura肾炎：Igai的异常糖基化，形成含Lga1的免疫复合物，并激活Mesangial细胞
5. Somatic Mutations in Human IgM Anti-DNA Antibody O-81 Expressing Lupus Nephritis-Associated Idiotypes [D] . 宗像靖彦 1994

机译：人IgM抗DNA抗体O-81表达与狼疮性肾炎相关的独特型的体细胞突变。
6. Anti‐dsDNA anti‐nucleosome anti‐C1q and anti‐histone antibodies as markers of active lupus nephritis and systemic lupus erythematosus disease activity [O] . Xiaoying Shang, Lisheng Ren, Guirong Sun, 2021

机译：抗DSDNA抗核小体抗C1Q和抗组蛋白抗体作为活性狼疮肾炎和全身性红斑狼疮病的标志物
7. Pathogenic Mechanisms in Lupus Nephritis: Nucleosomes Bind Aberrant Laminin β1 With High Affinity and Colocalize in the Electron-Dense Deposits. [O] . Olin, Anders, Mörgelin, Matthias, Truedsson, Lennart, 2014

机译：狼疮性肾炎的致病机制：核小体与高亲和力结合异常的层粘连蛋白β1并在电子密集沉积物中共定位。

Lupus nephritis: Nucleosomes trapped by aberrantly expressed laminin-β1

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