Serum levels of proANP and albumin are independent predictors of mortality in the high-risk patients (elderly and diabetics) treated by haemodialysis (HD) and continuous peritoneal dialysis in 4-year prospective observation.

摘要

Recently, Locatelli and Vigano [1] discussed the significance of natriuretic peptides as the marker for mortality in ESRD patients. They referred to the results published by Paniagua et al. [2] who noticed in a large cohort of CAPD, AD and HD patients that the N-terminal fragment of B-type natriuretic peptide (NT-proBNP) was a predictor of death risk independently of fluid volume overload and dialysis modality. The independency from fluid overload is explained by the relation of NT-proBNP elevation to both fluid overload and myocardial damage. In context of this observation, we would like to present the results of an as yet unpublished study performed in 86 dialysis patients (46 on maintenance HD and 40 treated by CAPD).