1-Acyl-3-O-[beta-glueopyranosyl-(1 '' 6 ')-beta-glueopyranosyl]-glyeerols and Cordycedipeptides B and C, New Metabolites from Bacillus pumilus

摘要

Four 1-monoacy1-3-O-[beta-glucopyranosyl-(1 -> 6)-beta-glucopyranosyl]-glycerols (1) and four 1,2-diacyl-3-O-[beta-glucopyranosyl-(1 -> 6)-beta-glucopyranosyl]glycerols (2a) with acyl residues consisting of 1:1 mixtures of 1-iso-pentadecanoyl- and 1-anteiso-pentadecanoyl residues and the respective heptadecanoic acid isomers s as main components, have been characterized in the extracts of Bacillus pun:this strain DKS1. Twenty-seven further metabolites, among them the diketopiperazines cordycedipeptide A (3), B (4), and C (5), were obtained. All compounds were elucidated by NMR and MS techniques and fully characterized and tested for antimicrobial activity against Legionella pnewnophila.