Degradation of monoCuLm 1 by APC/CTAD1regulates rice tillering

摘要

A rice tiller is a specialized grain-bearing branch that contributes greatly to grain yield. TheMONOCULM 1 (MOC1) gene is the first identified key regulator controlling rice tiller number;however, the underlying mechanism remains to be elucidated. Here we report a novel rice gene,Tillering and Dwarf 1 (TAD1), which encodes a co-activator of the anaphase-promoting complex(APC/C), a multi-subunit E3 ligase. Although the elucidation of co-activators and individualsubunits of plant APC/C involved in regulating plant development have emerged recently, theunderstanding of whether and how this large cell-cycle machinery controls plant developmentis still very limited. our study demonstrates that TAD1 interacts with moC1, forms a complexwith osAPC10 and functions as a co-activator of APC/C to target moC1 for degradation ina cell-cycle-dependent manner. our findings uncovered a new mechanism underlying shootbranching and shed light on the understanding of how the cell-cycle machinery regulates plantarchitecture.