MAO-A Inhibition Profiles of Some Benzophenone Glucosides from Gentiana verna subsp.pontica

摘要

Gentiana verna L. subsp. pontica (Soltok.) Hayek, G. pyrenaica L., and G. verna L. subsp. balcanica Pritchard from Turkey were tested for their MAO-A inhibitory effects. A photometric peroxidase linked MAO-A bioassay performed on the H_2O extracts prepared from the methanolic extracts of the title plants revealed the potential effect of G. verna subsp. pontica and three benzophenone glucosides; 2,3'-dihydroxy-4-methoxy-benzophenone-6-0-β-glucopyranoside (1), 2,4,3',4'-tetrahydroxy-benzophenone-6-O-β-glucopyranoside (maclurin-6-O-β-glucopyranoside) (2) and 2,4,3'-trihydroxy-benzophenone-6-O-β-glucopyranoside (3) isolated from G. verna subsp. pontica. Among the benzophenone glucosides 1 and 2 exhibited significant inhibition of MAO-A (IC_(50)=31.3±4 μM and 41±4.7 μM resp.).