Fibrosis under arrest.

摘要

Direct damage to the kidneys caused by a critical illness or persistent irritant is the most complicated cause of renal failure and accounts for 25-40% of all cases. When acute renal injury occurs, normal tissue repair mechanisms are usually able to restore proper kidney function, provided that the injury is quickly discovered and treated successfully. However, if these repair mechanisms are disrupted or the injury-causing irritants persist, acute renal injury can progress into a chronic disorder, characterized by marked organ remodeling and fibrosis.