Sensory systems: Making a choice and sticking with it.

摘要

H3K4 methylation (which activates transcription). The enzyme lysine-specific demethylase 1 (LSD1; also known as KDM1A) can catalyse demethylation of both H3K9 and H3K4, suggesting that it could have a role in OR regulation. Indeed, here the authors showed that its expression pattern supports such a role: LSD1 is expressed at high levels in immature OSNs but is rapidly downregulated as the neurons mature after OR expression.To examine the functional role of LSD1 in OR gene regulation, the authors generated mice in which Lsdl was deleted at different stages of OSN development. Removal of Lsdl before OR expression resulted in a widespread loss of OR gene transcription and caused the premature arrest of OSN