Synaptic plasticity: Assertive authorities.

摘要

Epigenetic and microRNA (miRNA)-dependent regulation of brain function are two processes that have received considerable attention in recent years. The NAD-dependent histone deacetylase sirtuin 1 (SIRT1) has previously been implicated in neurological disorders but its physiological role in normal brain function was unknown. Gao et al. now show that one mechanism by which SIRT1 modulates synaptic plasticity is through miRNA-dependent regulation of the transcription factor cyclic AMP-responsive element-binding (CREB) protein.