Pain: Blocking painful interactions.

摘要

The neuronal voltage gated calcium channel Cav2.2 is an established contributor to many persistent pain syndromes; however, existing calcium channel blockers are relatively nonspecific and result in undesirable side effects. A paper published in Nature Medicine now reveals a new approach to target the function of Cav2.2 using a small synthetic peptide, alleviating inflammatory and neuropathic pain with minimal adverse effects.