The nuclear lamina is a major component of the nuclear envelope and is mainly composed of lamin nuclear intermediate filament proteins. But, to this day, we do not have a clear three-dimensional picture of how lamins are assembled into filamentous polymers beneath the nuclear envelope and how these filaments are collectively assembled to form a functional lamina. Mutations in lamin A and C are directly associated with severe nuclear deformation and human disease, underscoring the importance of understanding this process and how it can malfunction.
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