An antibacterial compound against Pasteurella haemolytica produced by Streptomyces sp. 51086

摘要

Pasteurella haemolytica is well known to cause severe pneumonia, consolidation and oedema of the lung, and fibrinous pleurisy under the stress and infection of vires in the cattle. In the course of our screening for antimicrobial agents against P haemolytica, compound 51086 has been isolated from the fermentation broth of Streptomyces sp. 51086. The compound 51086 was purified by SiO_2, Sephadex LH-20 and ODS column chromatographies and HPLC, subsequently. The structure of compound 51086 was determined as hygromycin A by combination of ~1H NMR, ~(13)C NMR, HMBC, and ESI-MS. This compound showed significant antibacterial activity against P haemolytica and P multocida.