In vivo effect of gamma ray pretreatment on sister-chromatid exchange induction by mitomycin C in murine bone marrow cells.

摘要

The effect of gamma ray pretreatment on sister-chromatid exchange induction by mitomycin C (MMC) was determined in murine bone marrow cells in vivo. A 30% reduction in the expected SCE frequency was observed assuming an additive effect. These results support the prediction of the replicative model for SCE formation with regard to the interactions between mutagens, and confirm previous results focused on the adaptive response.