Stacking decreases the cooperativity of melting of homopolymeric DNA

摘要

We report on theoretical investigation of interactions of different mechanisms and their influence onto DNA cooperativity of helix-coil transition (melting). Using the modified version of microscopic Potts-like one-dimensional model we showed that increased stacking results in decreased correlation length. The decrease in cooperativity is explained as a result of combined hydrogen bonding and stacking.