Electrometric Studies on the Ternary Complexes of M(II) With Chlorpromazine and Some Amino Acids

摘要

The stability constants for the binary M(II)-chlorpromazine hydrochloride (CPZ) and the ternary complexes M(II)-chlorpromazine-amino acid, have been studied using pH-measurements. The amino acids (aa) are: glycine, glutamic acid, histidine and the metal ions are: Cu(II), Zn(II), Co(II), Ni(II) and UO_2(II). All experiments were carried out in the presence of 0.1 mol dm~(-3) KNO_3. The resulting stability constants of the binary and the ternary complexes were compared. It was observed that the stability of the ternary complexes-except for glutamic acid - are lower than of the binary ones.