Tea and coffee contain bioactive compounds and both beverages have recently been associated with a reduced risk of prostate cancer (PCa).We studied associations of tea and coffee consumption with PCa risk in a population-based case-control study from King County, Washington, USA. Prostate cancer cases were diagnosed in 2002-2005 and matched to controls by 5-year age groups. Logistic regression was used to generate odds ratios (ORs) and 95 % confidence intervals (CIs).Among controls, 19 and 58 % consumed at least one cup per day of tea and coffee, respectively. The analysis of tea included 892 cases and 863 controls, and tea consumption was associated with a reduced overall PCa risk with an adjusted OR of 0.63 (95 % CI: 0.45, 0.90; P for trend = 0.02) for men in the highest compared to lowest category of tea intake (≥2 cups/day vs. ≤1 cup/week). Risk estimates did not vary substantially by Gleason grade or disease stage. Coffee consumption was not associated with risk of overall PCa or PCa in subgroups defined by tumor grade or stage.Our results contribute further evidence that tea consumption may be a modifiable exposure that reduces PCa risk.
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机译：茶和咖啡含有生物活性化合物，最近两种饮料都与降低前列腺癌（PCa）的风险有关。我们在华盛顿州金县的一项基于人群的病例对照研究中研究了茶和咖啡的摄入与PCa风险的关系。美国。在2002-2005年诊断出前列腺癌病例，并按5岁年龄组与对照组相匹配。使用Logistic回归生成比值比（OR）和95％的置信区间（CI）。在对照组中，分别有19％和58％的人每天至少喝一杯茶和咖啡。茶叶分析包括892例病例和863例对照者，与男性相比，饮茶与降低PCa总体风险相关，调整后的OR值为0.63（95％CI：0.45，0.90; P = 0.02）茶摄入量最低的类别（≥2杯/天vs.≤1杯/周）。风险评估在格里森分级或疾病阶段之间没有显着差异。咖啡的摄入量与肿瘤分级或分期所定义的亚组中总体PCa或PCa的风险无关。
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