Determination of ethamsylate in pharmaceutical preparations by irreversible biamperometry

摘要

A novel flow-injection irreversible biamperometric method is described for the determination of ethamsylate. The proposed method is based on the oxidation of ethamsylate at one platinum electrode and the reduction of permanganate at another to form an irreversible biamperometric detection system. Ethamsylate can be determined over the range 1.0 X 10(-6)-1.0 X 10(-4) mol l(-1) with a sample measurement frequency of 180 samples h(-1). The detection limit for ethamsylate is 4.0 x 10(-7) mol l(-1). The stability of the proposed method is shown by a RSD of 0.52% for 11 replicate determinations of 2.0 X 10(-5) mol l(-1) ethamsylate. The proposed method was applied to the determination of ethamsylate in pharmaceutical preparations. (c) 2004 Elsevier B.V. All rights reserved.