Influence of calcitonin gene-related peptide (CGRP) and its C-terminal fragment [Tyr0]CGRP(28.37) on blood flow in the porcine uterine artery.

摘要

The aims of this study were to determine the effect of calcitonin gene-related peptide (CGRP) on the blood flow in the uterine artery of immature and mature pigs and investigate the interaction between CGRP and its C-terminal fragment [Tyr0]CGRP(28-37) in the uterine artery of mature animals in vivo. CGRP relaxed the uterine artery to a similar degree in both immature and mature pigs. [Tyr0]CGRP(28-37) administered as an intra-arterial bolus injection neither affected blood pressure nor antagonized the actions of CGRP. It was concluded that CGRP-induced relaxation of the porcine uterine artery occurred independently of steroid hormone concentrations, and [Tyr0]CGRP(28-37) did not affect CGRP activity..