Bio-related polymers: Poly(vinyl alcohol)-graft-poly(ethylene glycol)-supported hydroxyproline catalysis of stereoselective aldol reactions

摘要

The good swelling and high loading of poly(vinyl alcohol)-graft-poly(ethylene glycol) (PVA-g-PEG) resins proved to be effective for performing supported proline-catalyzed aldol reactions stereoselectively in a wide range of polar non-protic, protic and non-polar solvents as well as in neat substrate. The catalysts could be recovered by filtration and recycled, without significant loss of activity. The use of poly(vinyl alcohol)-graft- poly(ethylene glycol) matrix improved the solubility of the proline-derived catalysts and expanded the scope of permissible solvents for performing selective aldol chemistry.