Ultrasound-Triggered Release of Ibuprofen from aChitosan-Mesoporous Silica Composite - a Novel Approach for Controlled Drug Release

摘要

In this work, an attempt was made to synthesize a novel Chitosan-Mesoporous silica (CS-MS) hybrid composite to design a drug delivery system basedon ultrasound triggered stimuli-responsive smart release. The in-vitro drug releaseproperties of both the Mesoporous Silica (MS) and Chitosan (CS) hybrids wereinvestigated. Ibuprofen (lbu) was used as a model drug. The results from powderX-Ray diffraction (XRD) patterns, and BET N2 adsorption isotherms exhibited that MScan accommodate drug molecules into the lumen of the channels and pores. Drugrelease, stimulated by temperature and pH of the release media was also investi-gated. We studied the Ultrasound (US) triggered release of lbu in a simulated bodyfluid (pH 7.4). The results exhibited that US can be used as a non-invasive techniquefor drug release from polymeric materials. The enhancing effect of ultrasound ondrug release is due to the Cavitation effect, without causing any significantdestruction on the polymer morphology.