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Targeting the latest hallmark of cancer: Another attempt at 'magic bullet drugs targeting cancers metabolic phenotype

机译:针对癌症的最新特征:针对癌症代谢表型的“神奇子弹药物”的另一种尝试

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摘要

The metabolism of tumors is remarkably different from the metabolism of corresponding normal cells and tissues. Metabolic alterations are initiated by oncogenes and are required for malignant transformation, allowing cancer cells to resist some cell death signals while producing energy and fulfilling their biosynthetic needs with limiting resources. The distinct metabolic phenotype of cancers provides an interesting avenue for treatment, potentially with minimal side effects. As many cancers show similar metabolic characteristics, drugs targeting the cancer metabolic phenotype are, perhaps optimistically, expected to be 'magic bullet treatments. Over the last few years there have been a number of potential drugs developed to specifically target cancer metabolism. Several of these drugs are currently in clinical and preclinical trials. This review outlines examples of drugs developed for different targets of significance to cancer metabolism, with a focus on small molecule leads, chemical biology and clinical results for these drugs.
机译:肿瘤的代谢与相应的正常细胞和组织的代谢显着不同。代谢改变是由癌基因引发的,是恶性转化所必需的,使癌细胞能够抵抗某些细胞死亡信号,同时产生能量并以有限的资源满足其生物合成需求。癌症独特的代谢表型为治疗提供了一条有趣的途径,可能具有最小的副作用。由于许多癌症都表现出相似的代谢特征,因此,有望将靶向癌症代谢表型的药物视为“神奇的子弹疗法”。在过去的几年中,已经开发出许多潜在的药物来专门针对癌症代谢。这些药物中的几种目前正在临床和临床前试验中。这篇综述概述了针对癌症代谢具有重要意义的不同目标而开发的药物的例子,重点是这些药物的小分子导联,化学生物学和临床结果。

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