Effect of probiotic, prebiotic and synbiotic follow-up infant formulas on iron bioavailability in rats.

摘要

Effects of diets containing infant formulas supplemented with probiotic bacteria and prebiotics were investigated on Fe bioavailability in rats. The diets consisted of 7 powder follow-up infant formulas containing probiotics (Bifidobacterium bifidum and Bifidobacterium longum), prebiotics (galactooligosaccharides (4'-GOS) at 1.2, 5 and 10%) or synbiotics (bifidobacteria and 4'-GOS at 1.2, 5 and 10%), which were administered to weanling rats over 30 days. Fe balancing analyses (determination of mineral apparent absorption and retention ratios) were carried out in 3 periods of 72 h each. Administration of any of the test diets increased apparent Fe absorption or retention in all test periods; however, only 10% prebiotic and synbiotic diets significantly (P < 0.05) increased apparent Fe absorption and retention during the 3 periods of mineral balancing when compared to the control group. A linear regression study demonstrated that stimulation of Fe absorption took place mainly in the colon portion of the gut, since a multiple linear relationship was observed between Fe absorption, crypt depth of proximal colon and pH colon content (R2 = 0.56).