A New Tool for Purification: HPCCC as an Alternative Liquid Chromatography Technology

摘要

Pharmaceutical companies are looking for ways to increase the processing speed of developing new products and at the same time reducing the ever increasing costs of this process. This cost is a function of the large number of potential candidates, each requiring the investment of money and resource, when all but a one or two will fall by the wayside. The main cause of this waste is that for each candidate that makes it to the final hurdle of phase III trials, as many as 10,000 will have been tested and discarded. Therefore chemists are now looking for processes that can purify crude samples without investment in developing the chemistry of each candidate, while still enabling toxicology and efficacy testing to occur, thus reducing the investment in each candidate until it is qualified. Secondly, as products proceed through development there is a need for growing quantities of the candidate material, from milligrams to tens of grams.