Stereoselective Addition of Nucleophiles to Aziridinyl-2-carboxaldimine

摘要

Commercial success to produce both enantiomers of aziridine-2-carboxylates in optically pure forms prompts us to extend their synthetic utilities for the preparation of enantiopure nitrogen containing molecules.In last few years we have studied with chiral aziridine-2-carboxylates to provide enantiomerically pure a- or beta-amino ester and their derivatives.Synthetic study has been extended to construct diamine compounds based on the reaction with the substrate,aziridinyl-2-carboxaldimine.Recently we successfully prepared aminomethylaziridine and 4,5-disubstitued imidazolidin-2-ones by the addition of organomagnesium reagents to aziridinyl-2-carboxaldimine.