Synthesis of Lysophosphatidylcholine Analogues Using D-Mannitol as a Chiral Template and Their Biological Activity for Sepsis

摘要

LPC analogues including natural and unnatural LPC,3-L-2-PC,acetylated LPC and ethylene glycol derivative are prepared from D-mannitol using in convenient procedures by only changing the synthetic sequences,and their protective activities against cecal ligation and puncture(CLP)-induced severe sepsis are compared.The chirality at C2 position in LPC is found to be required as(S)-configuration for sepsis inhibition,comparing from the protection activity between LPC 6 and unnatural LPC 8.The hydroxyl functionality is also very important and required at C2 or C3 position as shown in the protection activities of ethylene glycol analogue 11 and 3-L-2-PC 9.