Identification of Pyrrole[3,4-c]pyrazoles as Potent Tropomyosin Receptor Kinase A (TrkA) Inhibitors

Choe Hyeonjeong; Son You Hwa; Byun Byung Jin; Choi Sang Un; Lee Kwangho

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Identification of Pyrrole[3,4-c]pyrazoles as Potent Tropomyosin Receptor Kinase A (TrkA) Inhibitors

机译：吡咯[3,4-c]吡唑类化合物作为强效肌球蛋白受体激酶A（TrkA）抑制剂的鉴定

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来源
《Bulletin of the Korean Chemical Society》 |2016年第8期|共3页
作者
Choe Hyeonjeong; Son You Hwa; Byun Byung Jin; Choi Sang Un; Lee Kwangho;
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正文语种 eng
中图分类化学;
关键词
Tropomyosin receptor kinase A; Tropomyosin Receptor Kinase A inhibitor; Pyrrolo3; 4-cpyrazoles; Kinase inhibitor; Anticancer agent;

机译：肌球蛋白受体激酶A;肌球蛋白受体激酶A抑制剂;吡咯并[3;4-c]吡唑类;激酶抑制剂;抗癌药;

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1. Identification of Pyrrole[3,4-c]pyrazoles as Potent Tropomyosin Receptor Kinase A (TrkA) Inhibitors [J] . Choe Hyeonjeong, Son You Hwa, Byun Byung Jin, Bulletin of the Korean Chemical Society . 2016,第8期

机译：吡咯[3,4-c]吡唑类化合物作为强效肌球蛋白受体激酶A（TrkA）抑制剂的鉴定
2. Identification of a Novel Series of Potent TrkA Receptor Tyrosine Kinase Inhibitors [J] . Stéphane L.Raeppel, FrédéricGaudette, HannahNguyen, International journal of medicinal chemistry. . 2012,第1期

机译：新型有效的TrkA受体酪氨酸激酶抑制剂系列的鉴定。
3. A new class of potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: structure-activity relationships for a series of 9-alkoxymethyl-12-(3-hydroxypropyl)indeno(2,1-a)pyrrolo(3,4-c)carbazole-5- ones and the identification of C [J] . Gingrich DE, Reddy DR, Iqbal MA, Journal of Medicinal Chemistry . 2003,第25期

机译：一类新的强效血管内皮生长因子受体酪氨酸激酶抑制剂：一系列9-烷氧基甲基-12-（3-羟丙基）茚并（2,1-a）吡咯并（3,4-c）咔唑的结构-活性关系-5-一和C的识别
4. Taking Quinazoline as a General Support-Nog to Design Potent and Selective Kinase Inhibitors: Application to FMS-like Tyrosine Kinase 3 [C] . Wei-Wei Li, Luo-Ding Yu, Li-Juan Chen, ICMSI;International conference of molecular simulations and applied informatics technologies . 2010

机译：以喹唑啉作为一般支持物来设计有效和选择性激酶抑制剂：在类似FMS的酪氨酸激酶3中的应用
5. The multi-targeted receptor tyrosine kinase inhibitor, linifanib (ABT-869), induces apoptosis and inhibits proliferation of leukemia cells through phosphoinositide-3 kinase (PI3K)/AKT-dependent signaling pathways. [D] . Hernandez, Jenny Elizabeth. 2010

机译：多靶点受体酪氨酸激酶抑制剂利尼法尼（ABT-869）通过磷酸肌醇3激酶（PI3K）/ AKT依赖性信号传导途径诱导凋亡并抑制白血病细胞的增殖。
6. Identification of a Novel Series of Potent TrkA Receptor Tyrosine Kinase Inhibitors [O] . Stéphane L. Raeppel, Frédéric Gaudette, Hannah Nguyen, 2012

机译：新型系列的有效TrkA受体酪氨酸激酶抑制剂的鉴定。
7. Blocking the tropomyosin receptor kinase A (TrkA) receptor inhibits pain behaviour in two rat models of osteoarthritis [O] . Nwosu Lilian Ngozi, Mapp Paul I., Chapman Victoria, 2015

机译：阻断原肌球蛋白受体激酶A（TrkA）受体可在两种骨关节炎大鼠模型中抑制疼痛行为

Identification of Pyrrole[3,4-c]pyrazoles as Potent Tropomyosin Receptor Kinase A (TrkA) Inhibitors

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