Sequence, tissue distribution and developmental changes in rat intestinal oligopeptide transporter

摘要

Complementary DNA clones encoding the rat PepTl small-intestinal oligopeptide transporter were isolated from a jejunal library by cross-hybridization with a rabbit PepTl cDNA probe. The cDNA sequence indicates that rat PepTl is composed of 710 amino acids and shows 77% and 83% amino acid sequence identity with rabbit and human PepTl, respectively. Northern blot analysis detected rat PepTl mRNA in the small intestine and kidney. Intestinal PepTl mRNA levels were highest in 4-day-old rats, and then decreased reaching the adult level by day 28 after birth. These results indicate that the expressions of PepTl gene change markedly during development.