Perspectives on cellular dysfunction in nonalcoholic steatohepatitis: a case of 'multiorganelle failure'? Proceedings of a virtual workshop on nonalcoholic steatohepatitis.

摘要

Nonalcoholic fatty liver disease (NAFLD) will be 60 years old next year: it was first reported in 1952 [l], and what we now allude to as nonalcoholic steato-hepatitis (NASH) was described in 1962 by Thaler [2]. In 1979, Itoh described "five diabetic non-alcoholic women with micronodular cirrhosis" [3]. All aged over 50 years and obese, they displayed a phe-notype that was later named NASH for the first time in 1980 by Ludwig [4]. In the following years, NASH was to be defined as 'diabetic hepatitis', 'alcohol-like liver disease in the non-alcoholic', 'bright liver syndrome' and 'insulin-resistance-associated hepatic iron overload', which can all be considered synonyms (Box l) [5-8]. In 1999, Brunt proposed the most pragmatic classification for use in clinical practice [9], and in 2005 Kleiner introduced a semi-quantitative scoring system designed to reduce interobserver variability among pathologists [10].